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Shizuo Akira Selected Research

Virus Diseases (Viral Diseases)

1/2017Mitochondrial damage elicits a TCDD-inducible poly(ADP-ribose) polymerase-mediated antiviral response.
12/2015The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication.
5/2015Alveolar macrophage-derived type I interferons orchestrate innate immunity to RSV through recruitment of antiviral monocytes.
8/2013The second messenger phosphatidylinositol-5-phosphate facilitates antiviral innate immune signaling.
6/2013Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation.
1/2013Type-I interferon is critical for FasL expression on lung cells to determine the severity of influenza.
6/2012[Nucleic acids recognition by innate immunity].
1/2012The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice.
10/2011Innate immunity and adjuvants.
6/2011Viral infection augments Nod1/2 signaling to potentiate lethality associated with secondary bacterial infections.
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Shizuo Akira Research Topics

Disease

145Infections
01/2020 - 06/2002
100Inflammation (Inflammations)
05/2021 - 05/2002
51Neoplasms (Cancer)
01/2021 - 01/2003
41Virus Diseases (Viral Diseases)
01/2017 - 01/2003
18Porcine Reproductive and Respiratory Syndrome (PRRS)
01/2017 - 02/2006
17Systemic Lupus Erythematosus (Libman-Sacks Disease)
10/2018 - 06/2004
17Melanoma (Melanoma, Malignant)
01/2018 - 09/2005
16Pneumonia (Pneumonitis)
01/2020 - 01/2002
13Sepsis (Septicemia)
10/2013 - 05/2002
12Bites and Stings (Sting)
01/2019 - 12/2009
11Fibrosis (Cirrhosis)
11/2021 - 12/2003
11Malaria
06/2017 - 04/2004
11Bacterial Infections (Bacterial Infection)
10/2014 - 12/2002
10Hypersensitivity (Allergy)
01/2014 - 05/2002
10Human Influenza (Influenza)
01/2013 - 03/2004
9Neoplasm Metastasis (Metastasis)
01/2021 - 11/2008
9Ischemia
01/2021 - 09/2002
9Necrosis
03/2015 - 07/2004
9Glomerulonephritis
10/2011 - 09/2004
9Autoimmune Diseases (Autoimmune Disease)
04/2010 - 02/2005
8Colitis
10/2018 - 02/2004
8Carcinogenesis
08/2017 - 06/2005
8Arthritis (Polyarthritis)
08/2017 - 08/2004
8Asthma (Bronchial Asthma)
05/2013 - 03/2006
7Peritonitis
12/2015 - 10/2003
7Atherosclerosis
01/2015 - 07/2003
7Insulin Resistance
03/2013 - 06/2006
6Reperfusion Injury
01/2021 - 07/2004
6Obesity
01/2021 - 06/2006
5Pain (Aches)
08/2018 - 06/2004
5Rheumatoid Arthritis
11/2016 - 12/2003
5Granuloma
09/2014 - 03/2004
5Type 1 Diabetes Mellitus (Autoimmune Diabetes)
09/2014 - 02/2005
5Eosinophilia
05/2013 - 05/2004

Drug/Important Bio-Agent (IBA)

91CytokinesIBA
01/2020 - 02/2002
77Toll-Like Receptors (Toll-Like Receptor)IBA
12/2018 - 05/2002
45Proteins (Proteins, Gene)FDA Link
11/2021 - 07/2002
32Interferon Type IIBA
01/2019 - 07/2005
29DNA (Deoxyribonucleic Acid)IBA
01/2019 - 02/2004
27Antiviral Agents (Antivirals)IBA
01/2018 - 10/2004
26Phosphotransferases (Kinase)IBA
01/2020 - 06/2004
25InterferonsIBA
01/2019 - 03/2004
25Interleukin-18 (Interleukin 18)IBA
10/2014 - 01/2002
21LigandsIBA
11/2021 - 03/2004
20ChemokinesIBA
11/2021 - 02/2002
20Pattern Recognition ReceptorsIBA
01/2017 - 03/2004
20NF-kappa B (NF-kB)IBA
07/2010 - 07/2002
19Tretinoin (Retinoic Acid)FDA LinkGeneric
01/2018 - 09/2005
19RNA (Ribonucleic Acid)IBA
01/2017 - 03/2004
19VaccinesIBA
04/2014 - 09/2004
18Interleukin-12 (IL 12)IBA
01/2017 - 01/2002
18Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
09/2012 - 04/2003
17Interleukin-6 (Interleukin 6)IBA
01/2019 - 04/2003
17AntigensIBA
05/2013 - 10/2004
16Prostaglandin-E SynthasesIBA
01/2020 - 06/2004
16Messenger RNA (mRNA)IBA
01/2020 - 01/2003
15Nucleic AcidsIBA
06/2012 - 06/2004
14Toll-Like Receptor 2IBA
08/2007 - 07/2002
13AutoantibodiesIBA
10/2018 - 12/2005
12LipopolysaccharidesIBA
01/2021 - 01/2004
12Myeloid Differentiation Factor 88IBA
12/2018 - 10/2002
12Transcription Factors (Transcription Factor)IBA
01/2018 - 01/2005
11Double-Stranded RNA (RNA, Double Stranded)IBA
06/2013 - 09/2003
11Prostaglandins EIBA
02/2013 - 06/2002
10Lipocalin-2IBA
11/2020 - 12/2004
10Toll-Like Receptor 9IBA
01/2019 - 02/2004
9InflammasomesIBA
01/2020 - 12/2007
9Interferon Regulatory Factor-3 (Interferon Regulatory Factor 3)IBA
01/2018 - 10/2004
9ProstaglandinsIBA
12/2015 - 06/2004
9Immunoglobulin G (IgG)IBA
11/2011 - 06/2005
8Dinoprostone (PGE2)FDA Link
01/2017 - 06/2004
8Poly I-CIBA
10/2014 - 01/2004
8Interleukin-1 (Interleukin 1)IBA
08/2014 - 08/2002
8Interleukin-10 (Interleukin 10)IBA
01/2014 - 09/2003
8Toll-Like Receptor 4IBA
07/2013 - 07/2004
8Toll-Like Receptor 7IBA
05/2013 - 03/2004
7Antigen-Antibody Complex (Immune Complex)IBA
10/2018 - 04/2008
7OligodeoxyribonucleotidesIBA
03/2014 - 08/2005
7FlagellinIBA
01/2014 - 11/2006
7RNA Helicases (RNA Helicase)IBA
12/2012 - 10/2005
7AntibodiesIBA
06/2012 - 11/2004
7Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
03/2010 - 01/2003
6Interleukin-33IBA
05/2021 - 02/2012
6Biological ProductsIBA
01/2019 - 12/2004
6Peptides (Polypeptides)IBA
08/2013 - 02/2005
6Viral RNAIBA
07/2013 - 09/2005
6EnzymesIBA
07/2013 - 07/2002
6Immunoglobulin E (IgE)IBA
05/2013 - 08/2002
5Bleomycin (Blenoxane)FDA LinkGeneric
11/2021 - 12/2007
5hemozoinIBA
06/2017 - 01/2005
5Pathogen-Associated Molecular Pattern MoleculesIBA
12/2016 - 06/2007
5CholesterolIBA
01/2015 - 07/2003
5LipidsIBA
08/2013 - 07/2004
5Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
07/2013 - 02/2008
5Interferon-gamma (Interferon, gamma)IBA
12/2012 - 01/2004
5IronIBA
11/2012 - 12/2004
5pristane (pristan)IBA
10/2011 - 04/2008

Therapy/Procedure

20Therapeutics
01/2021 - 08/2002
8Immunotherapy
01/2021 - 02/2003
8Ligation
07/2013 - 12/2003